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Which of the following statements regarding immunoglobulins is TRUE?


A) They consist of a unique sequence of amino acids.
B) They are produced in the red bone marrow.
C) They are attached to mucosal membranes at entry points into the body.
D) IgA binds to allergens.

E) B) and C)
F) C) and D)

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The term tolerance refers to:


A) surveillance and destruction of new cancer cells by the immune system.
B) the ability of the immune system to ignore "self" cells.
C) the ability of T and B lymphocytes to work together.
D) the role of lymphoid tissue in the body defenses.

E) B) and C)
F) B) and D)

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Which of the following statements is TRUE regarding a patient who is HIV positive?


A) No medication is required until the CD4 cell count drops below normal range.
B) Antibodies are present, destroying the virus and preventing transmission to others.
C) Antibodies in the blood indicate presence of virus and possible transmission to others.
D) Enzymes have not yet converted RNA to DNA for replication.

E) B) and D)
F) A) and B)

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Distinguishing clinical features of systemic lupus erythematosus include:


A) inflammation in multiple organs.
B) lack of a specific diagnostic blood test.
C) acute onset and nonprogressive course.
D) typical skin rash on the chest and back.

E) A) and C)
F) A) and B)

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The role of memory cells is to:


A) change into an antibody-secreting cell following activation.
B) immediately secrete antibodies following the first exposure to antigen.
C) recognize the antigen and stimulate the immune response.
D) bind complement to the antibody.

E) A) and C)
F) None of the above

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The most common cause of death in patients who have AIDS is:


A) HIV encephalopathy.
B) tuberculosis.
C) Pneumocystis carinii pneumonia.
D) Candida infection.

E) C) and D)
F) None of the above

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Systemic lupus erythematosus is caused by:


A) a chronic allergic condition.
B) development of an immune-deficient state.
C) a deficiency of T lymphocytes.
D) immune complex deposits of antinuclear antibodies.

E) B) and C)
F) A) and C)

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Host-versus-graft disease refers to:


A) hyperacute rejection of tissue.
B) T cells in grafted tissue attacking host cells.
C) infection resulting from immunosuppression therapy.
D) transplant rejection by the recipient's immune system.

E) B) and C)
F) C) and D)

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Incompatible blood transfusions result in:


A) hemolysis of erythrocytes.
B) a type I immune response.
C) deposits in multiple organs.
D) immune deficiency.

E) C) and D)
F) A) and D)

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Tissue transferred between two genetically identical twins is referred to as a/an:


A) allograft.
B) syngraft.
C) isograft.
D) autograft.

E) C) and D)
F) A) and D)

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When an allergen binds with IgE antibodies on mast cells, resulting in release of chemical mediators, this reaction is called:


A) cytotoxic hypersensitivity.
B) immune complex hypersensitivity.
C) type I hypersensitivity.
D) type IV hypersensitivity.

E) None of the above
F) B) and D)

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In cases of HIV infection, the "window period" refers to the time between:


A) entry of the virus into the blood and the initial manifestations.
B) entry of the virus into the body and the appearance of antibodies in the blood.
C) entry of the virus into the body and a significant drop in CD4 T-helper lymphocyte count.
D) diagnosis of "HIV positive" and diagnosis of "AIDS."

E) None of the above
F) A) and D)

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Humoral immunity is mediated by:


A) natural killer cells.
B) T lymphocytes (T cells) .
C) B lymphocytes (B cells) .
D) neutrophils.

E) A) and B)
F) A) and C)

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CD4-positive helper T cells function by:


A) direct cytotoxic action.
B) facilitating all immune system activity.
C) producing immunoglobulins.
D) inactivating allergens.

E) A) and B)
F) B) and D)

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Which of the following statements does NOT apply to major histocompatibility complex (MHC) proteins or molecules?


A) They are genes on chromosome 6.
B) All members of a family have identical MHCs.
C) They alert the immune system to virus-infected cells.
D) A close match is essential for successful tissue transplants.

E) A) and D)
F) A) and B)

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