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Individuals with SCID,severe combined immunodeficiency disease,have defective ________ genes,which cause loss of B-cell and T-cell function.

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The Ds transposable element of maize cannot transpose on its own because it lacks


A) transposase.
B) inverted repeats.
C) origin of replication.
D) antibiotic resistance.
E) Tn10.

F) All of the above
G) C) and E)

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DNA sequences that resemble normal genes but do not function are called________.

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The recombinases RAG-1 and RAG-2 are expressed in both plasma and memory B-cells.

A) True
B) False

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False

Antibiotic resistance in bacteria can be transferred using insertion sequences.

A) True
B) False

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The constant region of an antibody contains the antigen binding domains.

A) True
B) False

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HERVs,human endogenous retroviruses make up about 10-20% of the human genome.

A) True
B) False

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Group II introns are non-LTR retrotransposons that are found only in bacterial cells.

A) True
B) False

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5'-ACCGTAG-GATGCCA-3'is an example of an inverted repeat sequence.

A) True
B) False

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_______________ is an enzyme that can synthesize DNA from an RNA template.

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Reverse transcriptase

The loss of bases or gain of bases is common in immunoglobulin gene rearrangement.

A) True
B) False

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__________ receptor genes undergo rearrangement in a manor similar to B-cell immunoglobulin genes.

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Insertion sequences are transposable elements that can inactivate genes.

A) True
B) False

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In ____________transposition both strands of the original DNA move together whereas in _________ transposition one copy of the DNA moves to a new site while one copy stays in the genome.

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nonreplica...

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Transposable elements or _________ are DNA fragments that can move from one organism to another.

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Hybrid dysgenesis may lead to the formation of new species.

A) True
B) False

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True

Which of the following is not necessary for retroviral insertion into the host genome?


A) RNA polymerase II
B) retroviral pol gene
C) viral protease
D) RNase H
E) reverse transcriptase

F) A) and B)
G) B) and D)

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Which of the following is not true concerning immunoglobulin gene recombination signal sequences?


A) There is a conserved heptamer.
B) There is a conserved nonamer.
C) The conserved sequences are separated by a nonconserved sequence of either a 12 bp or a 23 bp sequence.
D) Recombination occurs between a 12 bp signal and a 23 bp signal.
E) Recombination only occurs between two heptamers.

F) C) and E)
G) None of the above

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Which of the following transposons does not contain LTRs or inverted repeats at its ends?


A) Ty
B) Alu elements
C) copia
D) Tn3
E) Ds

F) A) and C)
G) B) and E)

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In order for P element transfer to happen in Drosophila which of the following situations must occur?


A) a P crossed with a P female
B) a P male crossed with an M female
C) an M male crosses with a P female
D) an M male crossed with an M female
E) any male crossed with a P female

F) C) and D)
G) B) and D)

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